“enjoy the ride“
Faza 1. Inducere I.
• Vincristin (iv) – 2mg, zilele 1, 8, 15, 22
• Doxorubicin (iv, 30 min) – 25 mg/m2, zilele 1, 8, 15, 22
• L-Asparaginaza (iv, 30 min) – 5000 IU/ m2, zilele 15, 17, 19, 21, 23, 25, 27
• Prednison (po) – 60 mg/m2, zilele 1-28, apoi reducerea treptata a dozelor
• Methotrexate (intratecal) – 15 mg, ziua 1
Faza 2. Inducere II.
• Cyclophosphamide (iv) – 650 mg/m2, zilele 29, 43, 57
• Cytarabine (iv, 1h) – 75 mg/m2, zilele 31-34, 38-41, 45-48, 52-55
• 6-Mercaptopurine (po) – 60 mg/m2, zilele 29-57
• Methotrexat (intratecal) – 60 mg/m2, zilele 31, 38, 45, 52
Faza 3. Consolidare I. (HDARAC + Doxo) + (HDMTX + Asp + 6MP)
• Cytarabine (iv, 3h, la 12 ore) – 1000 mg/m2, zilele 1-4
• Doxorubicin (iv, 30 min) – 1000 mg/m2, zilele 3-5
Apoi, dupa recuperarea hematogica:
• Methotrexat (iv, 24h) – 1500 mg/m2, zilele 1, 15 + Leucovorin (iv, ;a 24 ore de la inceperea MTX) – 6 doze la interval de 6 ore
• L-Asparaginase (iv, 30 min) – 10000 U/m2, zilele 2, 16
• 6-Mercaptopurine (po) – 25 mg/m2, zilele 1-5, 15-19
Faza 4. Reinducere I.
• Vincristin (iv) – 2mg, zilele 1, 8, 15, 22
• Doxorubicin (iv, 30 min), 25 mg/m2, zilele 1, 8, 15, 22
• Prednison (po) 60 mg/m2, zilele 1-28, apoi reducerea treptata a dozelor
• MTX 15 mg + Cytarabina 50 mg + Dexametazona 4 mg (intratecal) – ziua 1
Faza 5. Reinducere II.
• Cyclophosphamide (iv) – 650 mg/m2, ziua 29
• Cytarabine (iv, 1h) – 75 mg/m2, zilele 31-34, 38 – 41
• 6-Thioguanina (po) – 60 mg/m2, zilele 29-57
• MTX 15 mg + Cytarabina 50 mg + Dexametazona 4 mg (intratecal) – ziua 29
Faza 6. Consolidare II. (Etopozid + Ara-C) + (Ciclofosfamida + Ara-C)
• Etopozid (iv, 1h) – 100 mg/m2, zilele 1-5
• Cytarabine (iv, 1h) – 150 mg/m2, zilele 1-5
Apoi, dupa revenirea hematologica
• Cyclophosphamide (iv) – 1000 mg/m2, ziua 1
• Cytarabine (iv, 24h) – 500 mg/m2, ziua 1
• MTX 15 mg + Cytarabina 50 mg + Dexametazona 4 mg (intratecal) – ziua 1
Faza 7. Intretinere – pana la 2 ani.
• 6-Mercaptopurine (po) – 60 mg/m2, zilele 1-5
• Metotrexat (po) – 12,5 mg/m2, ziua 6
